Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) combines the sensitivity of bulk ICP-MS measurements with the lateral resolution of laser ablation techniques for elemental imaging. The technique has shown great potential in biomedical applications but the sample-dependent ablation behaviour (matrix effects) and elemental fractionation (changes in the composition of the ion beam in the mass spectrometer) limit the applicability and success of the technique for some applications. With this project we aimed to study the complementarity of LA-ICP-MS and total-IBA methods for their potential to analyse gelatine (doped with various concentrations of C and Pt) and understand the matrix effects caused by the laser ablation methodology.
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