Surrey Ion Beam Centre

 

Facilities

The Surrey Ion Beam Centre is a national facility available for UK researchers to apply for time through EPSRC and European grant applications. Access is also available on a commercial basis. See the information on gaining access on the main UKNIBC site or contact us at the links below and ask for more information or for a quotation.

 

Follow the links below for more information about the facilities available in each of the following categories:

 

Implantation & Irradiation	Ion Beam Analysis	Mass Spectrometry	Focussed Ion Beams	Single Ion Implantation

	Q-Exactive Plus Orbitrap The Q-Exactive Plus Orbitrap mass spectrometer available in our centre offers excellent sensitivity an mass resolution (280,000 at m/z 400), Several different ionisation sources are availabel to be coupled with the instrumentation.	Liquid Chromotography Mass Spectrometry (LC-MS) The mass spectrometry facility at the Surrey Ion Beam Centre also includes liquid chromatography-mass spectrometry (LC-MS) facility. The LC instrument available is comprised of a Thermo Ultimate™ 3000 UHPLC. Materials extracted using DAPNe-MS can be analysed using LC-MS for enhanced sensitivity and selectivity. Areas of research include proteomics, cell contents and drug testing.

	DAPNe DAPNe is an extraction technique that uses a nano-manipulator to position a capillary (with a 1 µm internal diameter) on the region of interest. With the aid of a cell pressure injector, solvent is injected onto the sample for extraction (with an achievable 100 µm spot size, measured using a Nikon AZ100 microscope) and then re-aspirated back into the capillary.   The capillary containing the extracted material is then placed on a Nanospray Flex&trade Ion Source for mass spectrometry analysis. DAPNe has been used to extract spiked drugs in tissue homogenates and is being developed for other applications such as the analysis of single cells, hair and paint.
	Paper Spray Paper spray-mass spectrometry (PS-MS) was developed at Purdue University in 2010. It uses a triangular piece of paper (chromatography paper, most commonly) to collect the sample. The application of a voltage (2-5 kV) and a solvent causes the extraction of the analytes from the paper and into the mass spectrometer.   The technique has found application in dried blood spots analysis and more recently, in drug testing using fingerprint sample. The technique has also shown promising results for explosives detection, with excellent sensitivity (low pg) and with very high sample throughput (30 seconds per sample).